Demak's northern coastline is increasingly vulnerable to environmental threats such as land subsidence, coastal erosion, and tidal flooding. Addressing these complex challenges requires more than technical solutions—it demands a transdisciplinary approach that integrates scientific knowledge, community participation, and inclusive policy-making. This study investigates the key factors influencing the effectiveness of transdisciplinary collaboration in coastal resilience strategies in Demak, Indonesia. Utilizing participatory research methods, including case studies, stakeholder workshops, and thematic analysis of survey and interview data, the research identifies three critical enablers: meaningful stakeholder engagement, integration of diverse knowledge systems, and the application of innovative modeling tools. Challenges such as institutional silos, resource constraints, and power asymmetries are also explored. The study concludes that sustained commitment, cross-sectoral communication, and localized decision-making are essential for fostering adaptive, equitable, and context-specific coastal management. The findings offer a replicable framework for coastal regions globally, emphasizing that resilience must be co-created across disciplines and communities.